23 Jul Water-insoluble ultrafine fibroin powder/polylactic acid composite porous scaffold material and preparation method thereof
Abstract
The invention belongs to the field of biomedicine high-molecular materials, and relates to a water-insoluble ultrafine fibroin powder-enhanced macromolecular composite porous scaffold material for tissue engineering and a preparation method thereof. The preparation method comprises the following steps: dissolving polylactic acid into dioxane or a mixed solvent of dioxane/dimethyl sulfoxide, so as to obtain a polylactic acid solution; adding a certain mass of water-insoluble ultrafine fibroin powder to the polylactic acid solution; ultrasonically defoaming after evenly mixing, and then injecting the polylactic acid solution into a polytetrafluoroethylene mold; freezing at -10 DEG C to -50 DEG C for 1-5 hours; and finally, carrying out freeze drying in a freeze dryer at -45 to -55 DEG C, so as to obtain the water-insoluble ultrafine fibroin powder/polylactic acid composite porous scaffold material. The preparation technology disclosed by the invention is simple, and conditions are easy to control and the prepared porous scaffold material has better biocompatibility, is high in porosity, strong in hydrophilia, and beneficial to conglutination, growth and propagation of cells, has better mechanical strength, and can be widely applied to the field of tissue engineering.
Year: 2014
Country: CN
Doc No: 103638559