23 Jul Vinyl sulfone-substituted cysteine-N-carboxyanhydride, polymer thereof and application of polymer
Abstract
The invention discloses a vinyl sulfone-substituted cysteine-N-carboxyanhydride, a polymer thereof and application of the polymer. Preparation comprises the following steps: preparing a vinyl sulfone-substituted cysteine-N-carboxyanhydride monomer; preparing a vinyl sulfone-modified polymer from the monomer; and finally, performing side chain modification on the polymer to prepare a functional polymer, a functional polymer film and injectable hydrogel. According to the invention, vinyl sulfone functional groups are not influenced by the preparation of the -N-carboxyanhydride monomer and the polymer, so that steps of protection and deprotection are not needed in the whole preparation process of the polymer; the prepared vinyl sulfone-modified polymer can be easily prepared into the functional polymer, the functional polymer film and the injectable hydrogel through Michael addition reaction at room temperature without the presence of a catalyst; and these materials can be used for preparation of tissue engineering scaffolds and medicinal slow release carriers.
Year: 2013
Country: CN
Doc No: 103275028