23 Jul Tissue-factor-based tumor peptide vaccine as well as preparation method and application thereof
Abstract
The invention discloses a tissue-factor-based tumor peptide vaccine which is AnsB-TF fusion protein formed after a sequence fragment containing epitope targets in human TF genes is expressed. The invention also discloses a preparation method and application of the tumor peptide vaccine. According to the preparation method, a TF peptide fragment containing epitope targets is connected with an AnsB carrier through a genetic engineering means so as to obtain the tumor peptide vaccine taking tissue factors as target epitopes. The vaccine obtains prevention and treatment effects on tumors through active immunization on TF epitope targets. The active immunization not only can completely block the effect of TF on tumor surfaces, but also can be used for avoiding the trouble of multi-time administration.
Year: 2014
Country: CN
Doc No: 103520712