23 Jul Tissue engineering scaffold material, preparation method, application and application method thereof
Abstract
The invention relates to a tissue engineering scaffold material, a preparation method, an application and an application method thereof. The preparation method of the tissue engineering scaffold material includes providing chitosan, and grafting chitosan with methacryloyl anhydride to obtain methacryloyl chitosan; esterifying the methacryloyl chitosan with matrix metalloproteinase-degradable peptide to obtain modified methacryloyl chitosan; and mixing the modified methacryloyl chitosan with oxidized hyaluronic acid and an inorganic salt solution to form a mixed solution, so as to carry out a condensation crosslinking reaction on amino groups in the modified methacryloyl chitosan and aldehyde groups in the oxidized hyaluronic acid to obtain the tissue engineering scaffold material. The tissue engineering scaffold material has injectability and self-repair performance, and when the material is used for inducing tissue repair, the mechanical strength and degradation rate of the obtained tissue engineering scaffold are controllable.
Year: 2019
Country: CN
Doc No: 109966552