23 Jul Tissue engineering material with biologically active surface layer and preparation method thereof
Abstract
The invention discloses a tissue engineering material with a biologically active surface layer and a preparation method thereof. The tissue engineering material comprises a biodegradable high polymer material matrix and a dopamine layer adsorbed on the surface of the matrix, wherein the dopamine layer is connected with a biologically active polymer. The preparation method comprises the following steps: providing the biodegradable high polymer material matrix with a thoroughly wetted surface; providing a buffer system with dissolved dopamine and the biologically active polymer; and fully soaking the matrix in the buffer system, carrying out incubation at 30 to 40 DEG C for 1 to 5 h, then taking the matrix out and subjecting the matrix to air drying so as to obtain the tissue engineering material with the biologically active surface layer. The tissue engineering material has high mechanical properties and controllable degradation performance and good biological activity and is beneficial for adherence and propagation of cells; and the preparation method is simple, easy to operate, low in cost and favorable for large-scale implementation.
Year: 2016
Country: CN
Doc No: 105727362