23 Jul Tissue engineering conduction bundle and construction method and application thereof
Abstract
The invention relates to the technical field of bioengineering. At present, many problems and difficulties exist in treating atrioventricular block through gene transfection and cell transplantation, and the current situation of researchment of biological pacing therapy is considered, so that a method that a tissue engineering conduction bundle is constructed in vitro by utilizing conduction bundle cells and scaffold materials so as to be transplanted to heart for repairing or reconstructing heart conduction path is an ideal solution of atrioventricular block therapy subject. However, no researchment of construction of the tissue engineering conduction bundle is reported at home and abroad. The invention aims to provide the tissue engineering conduction bundle and a construction method thereof. The construction method is characterized in that: heart conduction cells obtained by inducing collagen sponge and marrow mesenchymal stem cells are utilized to construct the tissue engineering conduction bundle. The tissue engineering conduction bundle provided by the invention has the characteristic of electrocardio conduction, can be used for treatment of transplant, and brings hope to treatment of arrhythmia diseases caused by atrioventricular block.
Year: 2012
Country: CN
Doc No: 102488922