23 Jul Tissue engineering bracket imitating intima-media structure and function of natural blood vessels and preparation method thereof
Abstract
The invention discloses a tissue engineering bracket imitating intima-media structures and functions of natural blood vessels, and a preparation method of the bracket. The bracket is a porous membranoid substance which is prepared from degradable macromolecules, loaded with growth factors, provided with micron-order grooves in parallel in the surface and is of a nano topological structure on the outer surface. The preparation method comprises the following steps: uniformly stirring nano grains with growth factors and a biologic degradable polymer solution, subsequently casting on a mold surface with the grooves in parallel, freezing and drying to eliminate the solvent, further performing surface treatment and loading the growth factors so as to obtain the tissue engineering bracket. Due to the parallel micron-order groove structure, the surface nano topological structure and the loaded growth factors of the tissue engineering bracket disclosed by the invention, induction and prompting functions on growth and breading of vascular smooth muscle cells, which are similar to those of extracellular matrix of intima-media cells of the natural blood vessels, can be achieved, and the vascular smooth muscle cells are enabled to grow and breed in ordered orientation on the artificial bracket like the intima-media of the natural blood vessels.
Year: 2014
Country: CN
Doc No: 103656758