23 Jul Tissue engineering bracket applicable to human body organ construction and preparation method thereof
Abstract
The invention discloses a tissue engineering bracket applicable to human body organ construction, and the tissue engineering bracket has the bore diameter of 5 mu m-200 mu m, good bore connectivity and proper degradability, and can be applicable to growth of cells in the bracket. The invention further discloses a preparation method of the tissue engineering bracket applicable to human body organ construction. The preparation method comprises the following steps: firstly preparing sericin liquor, chitosan liquor and sodium glycerophosphate liquor into mixed liquor; then, converting the mixed liquor into a gel state; finally, obtaining the tissue engineering bracket by virtue of a process comprising freezing and drying, placing and softening, and high-pressure steam treating. By regulating the ratio of the sericin liquor, chitosan liquor and sodium glycerophosphate liquor or changing process conditions, the bore diameter size and degradation performance of the obtained tissue engineering bracket can be obtained in a controlled manner, so that the tissue engineering bracket satisfies the requirements of the tissue engineering bracket applicable to human body organ construction. The preparation method has the advantages of being gentle in reaction condition, simple in process and low in material cost, and is suitable for industrial scale-up production.
Year: 2014
Country: CN
Doc No: 103948963