23 Jul Tissue engineering blood vessel bionic incubator
Abstract
The invention discloses a biomimetic blood vessel cultivator in tissue engineering and comprises a bearing seat and a cultivating room; an inlet pipe connector and an outlet pipe connector are respectively arranged in the cultivating room; a blood vessel fixing device which is arranged at one end of a chamber of the cultivating room, and a device which can move axially, is used for fixing a blood vessel and exerting tension stress on the blood vessel and is arranged at the other end of the chamber of the cultivating room are respectively provided with two connecting nozzles that are the same. One end of the device which is used for fixing the blood vessel and exerting tension stress on the blood vessel extends out from the cultivating room and is connected with a connector; the connector is connected with a tension sensor through a coil spring; the tension sensor is connected with a shaft of a linear motor; the cultivator leads a culture fluid to flow inside and outside a cultured blood vessel cavity; and by exerting shearing stress, simultaneously the cultivator also can exert longitudinal tension stress on the cultivated blood vessel, and the cultivator improves the arrangement and the extracellular matrix secretion of seed cells of the blood vessel by stimulating the blood vessel with multiple stresses, thus truly realizing the biomimetic blood vessel cultivation in tissue engineering and avoiding the pollution that is caused by changing the culture fluid.
Year: 2009
Country: CN
Doc No: 101486965