23 Jul Tissue-engineered nerve graft and preparation method thereof
Abstract
The invention discloses a tissue-engineered nerve graft and a preparation method thereof, and belongs to the technical field of a biological material and tissue engineering. According to the invention, by optimizing the specification of stripes, the stripes can independently induce EMSCs to be differentiated into myelin-forming cells (Schwann cells) to the greatest extent so as to obtain an EMSCs/biological material stent compound. The EMSCs/biological material stent compound not only can be used as a three-dimensional cell culture model for in-vitro study on neural stem cell differentiation,nerve fiber growth and a myelin-forming molecule mechanism, but also can be used as the tissue-engineered graft for in-vivo transplanting to repair the nervous system injury. According to the invention, an EMSCs/micropatterned biological material membrane is rolled into a cylindrical multi-tunnel type nerve regenerated conduit for transplanting to repair the sciatic nerve injury; a result shows that according to the tissue-engineered nerve graft, nerve regeneration and lower limb motor function recovery can be promoted by injured part transplantation; and the tissue-engineered nerve graft hasexcellent clinical application prospect and research and development value.
Year: 2019
Country: CN
Doc No: 110507857