23 Jul Tissue engineered artificial optic nerve conduit and preparation method thereof
Abstract
The invention belongs to the field of biomedical engineering, and relates to a tissue engineered artificial optic nerve conduit and a preparation method thereof. The tissue engineered artificial optic nerve conduit comprises a hollow conduit woven from polylactic-polyglycolic acid filaments (PLGA), polyglycolic acid (PGA) filaments and transgenic schwann cell suspension, wherein chitosan polymer is coated on the surface of the conduit; an external bracket of artificial optic nerve is constructed by the PLGA hollow conduit; and the PGA filaments are filled in an internal bracket in which the artificial optic nerve is constructed. The conduit can effectively promote regeneration of damaged optic nerve axon, and has the advantages of persistently providing nerve nutritional support, guiding the regenerated nerve axon and the like; the conduit has high tissue compatibility and safety; the specifications of the transfected gene and the conduit can be adjusted according to requirements; and the conduit and the method can be used for experimental research of optic nerve regeneration and expected to promote regeneration and restoration of damaged optic nerve in clinical use.
Year: 2011
Country: CN
Doc No: 101966090