23 Jul Three-dimensional support material containing hierarchical porous structures and preparation and application
Abstract
The invention belongs to the technical field of medical materials, and discloses a three-dimensional support material containing hierarchical porous structures and preparation and application. According to the three-dimensional support material containing the hierarchical porous structure, mixed liquor of a water-insoluble high-molecular polymer solution or a water-insoluble high-molecular polymer and a water-soluble polymer is used as a skin layer composition, a micromolecular medicine or a water-soluble polymer solution, air or deionized water is used as a core layer composition, collection is carried out by a dynamic coagulating bath receiving device through coaxial electrostatic spinning, and then the material is obtained by aftertreatment through freeze drying, non-solvent induced phase separation-freeze drying, thermally induced phase separation or a solid-liquid separation method. The obtained three-dimensional support material has the hierarchical porous structures, the hierarchical porous structures are distributed among fibers, on fiber surfaces and inside the fibers respectively, and a natural extracellular matrix can be well simulated in morphology and dimensions, so that the material can be applied to tissue engineering repair materials.
Year: 2017
Country: CN
Doc No: 106390208