23 Jul Three-dimensional non-support bone repairing patch and preparation method thereof
Abstract
The invention relates to a three-dimensional non-support bone repairing patch and a preparation method thereof. The patch is composed of nanometer fibre with an extracellular matrix, wherein the nanometer fibre is composed of polycaprolactone and polyglycolic acid which are blended in proportion by weight according to (1:9) to (9:1). The preparation method comprises the following steps of: dissolving two polymers in an organic solvent, and stirring to prepare a transparent and uniform electrostatic spinning solution; spinning the spinning solution by utilizing an electrostatic spinning process, and receiving to obtain a fibre support; and soaking, drying, tailoring and disinfecting the fibre support, and culturing by utilizing marrow mesenchmal stem cells to manufacture a three-dimensional bone patch repairing material. The three-dimensional non-support repairing patch provided by the invention can regulate pore diameter and void percentage at discretion according to need, can be used as nerve conduits and tissue engineering cytoskeletons of bones, blood vessels, hearts, nerves and the like, and is suitable for growth of multiple cells; and the preparation method has the advantages of simple process, low cost, and good application prospects.
Year: 2012
Country: CN
Doc No: 102631703