23 Jul Three-dimensional network-like chitosan-calcium carbonate nano composite material as well as preparation method and cell compatibility thereof
Abstract
The invention discloses a three-dimensional network-like chitosan-calcium carbonate nano composite material as well as a preparation method and cell compatibility thereof. In the preparation method, the chitosan-calcium carbonate nano composite material is prepared by taking chitosan as a carbon source, calcium chloride dehydrate, ammonium bicarbonate and secondary distilled water as raw materials on the surface of stainless steel by virtue of a one-step coelectrodeposition method. The biocompatibility of the chitosan-calcium carbonate network-like nano composite structure is studied by virtue of in-vitro cell culture. The electrodeposition method is simple and controllable; and the chitosan-calcium carbonate fibrous network-like structure is firmly combined with a substrate, and has strong mechanical performance and excellent biocompatibility. A good experimental result is achieved by using the chitosan-calcium carbonate fibrous network-like structure as a cytoskeleton material. The preparation method is simple in process, low in cost and environmentally-friendly; and the three-dimensional network-like chitosan-calcium carbonate nano composite material is in accordance with the standard of a biomaterial of a cell culture medium in tissue engineering, and can be applied to bone repair.
Year: 2012
Country: CN
Doc No: 102343115