23 Jul Three-dimensional large-aperture nanoscale fibrous scaffold and method for preparing same
Abstract
The invention discloses a three-dimensional large-aperture nanoscale fibrous scaffold and a method for preparing the same. The average diameter of fibers in the scaffold is about 1 nanometer to 900 nanometers, the voidage is about 50%-98%, the scaffold is of a three-dimensional structure, and the thickness of the scaffold is 0.01 micrometer to 10 centimeters. The method includes the following steps of dissolving biodegradable polyester and additives into organic solvent to prepare spinning solution. An electrostatic spinning process is used for spinning the spinning solution to obtain nanoscale/submicron-order fibrofelt. The fibrofelt is soaked in solvent within 48 hours after being spun, is pre-frozen at first, and then is frozen and dried, so that the three-dimensional fibrous scaffold with mutually communicated large holes is obtained. The three-dimensional tissue engineering scaffold material with the communicated large holes is prepared, the structures of the internal holes are uniform, and the three-dimensional large-aperture nanscale fibrous scaffold can be used as a tissue engineering cytoskeleton for bones, cartilages, blood vessels, hearts, nerves and the like, and is suitable for growth of various cells.
Year: 2012
Country: CN
Doc No: 102813562