23 Jul Three-dimensional fiber-based aerogel tissue engineering scaffold and preparation method thereof
Abstract
The invention relates to a preparation method of a three-dimensional fiber-based aerogel tissue engineering scaffold and a product thereof. The preparation method comprises the following steps of: firstly dispersing fibers in solvents to form turbid liquid; secondly curing the turbid liquid to form cured pieces; thirdly removing cured solvents to form non-crosslinked fiber-based aerogel; finally carrying out crosslinking stabilization treatment and then carrying out sterilization treatment, thus obtaining the three-dimensional fiber-based aerogel tissue engineering scaffold. The product is a three-dimensional network-shaped material formed through mutual penetration and stagger of fibers. The fiber crossing points are effectively interconnected through non-hydrogen-bond bonding. The three-dimensional fiber-based aerogel tissue engineering scaffold has volume density of 0.1-500mg/cm<3>, average pore size of 0.01-2000mu m and specific surface area of 0.2-2000m<2>/g. The preparation method and the product have the advantages that the preparation process is simple; the raw material limitations are less; the aerogel tissue engineering scaffold product has good flexibility, connectivity and tissue growing environment and has broad application prospects in the tissue engineering field.
Year: 2013
Country: CN
Doc No: 103285424