23 Jul Three-dimensional chitosan hydrogel and preparation method thereof
Abstract
The invention discloses a method for preparing three-dimensional chitosan hydrogel by using a high temperature crosslinking method and the obtained chitosan hydrogel. The method comprises the following steps of: (a) dispersing chitosan powder into a deionized water; (b) adjusting the pH of chitosan dispersion obtained in the step (a) to be subacid; (c) carrying out high temperature crosslinking on the solution obtained in the step (b) at the high temperature of 80-125 DEG C; and (d) after the crosslinking reaction is completed, soaking and cleaning an obtained product by using a posttreatment liquid so as to remove a residual acid liquid. The high temperature crosslinking method is simple in the preparation process; the reaction time is short; raw materials are unnecessary for special treatment; highly-toxic chemical substances such as crosslinking agents are not introduced to a preparation course; no any chemical toxicant remains in a final product; and the three-dimensional chitosan hydrogel is even in pore structure, good in connectivity and easy to form, and is very suitably used as a support material of soft tissue engineering such as skin and cartilage.
Year: 2012
Country: CN
Doc No: 102604149