23 Jul Thiol-aldehyde group cross-linked hydrogel material, preparation method and applications thereof
Abstract
The invention relates to a thiol-aldehyde group cross-linked hydrogel material, a preparation method and applications thereof. The preparation method comprises: dissolving a component A thiol-containing polymer derivative in a biocompatible medium to obtain a solution A; dissolving a component B aldehyde group-containing polymer derivative in a biocompatible medium to obtain a solution B; and mixing with the solution A and the solution B to obtain the hydrogel, wherein the hydrogel has plasticity at the initial stage of cross-linking, can form a removable hydrogel system at the later stage ofcross-linking, and can form an interpenetrating network hydrogel system with enhanced mechanical property, a component C and/or a component D can be added to the hydrogel precursor solution, the component C is a double bond-containing substance or an amino-containing substance or a substance containing a double bond and amino, and the component D is a tissue repairing beneficial ingredient. The invention further provides a kit for preparing the hydrogel, applications of the hydrogel in tissue engineering and regenerative medicine, 3D cell culture, 3D printing, and applications of the hydrogelas cell carriers, protein carriers or drug carriers.
Year: 2019
Country: CN
Doc No: 110128682