TENOGENIC MEDIUM FOR MESENCHYMAL STEM CELLS DIFFERENTATION INTO TENOGENIC LINEAGE

TENOGENIC MEDIUM FOR MESENCHYMAL STEM CELLS DIFFERENTATION INTO TENOGENIC LINEAGE

Abstract

Tenocytes are highly differentiated cells which have a limited potential for replication. Therefore, in vitro propagation of tenocytes may still not be able to supply enough seed cells for tendon tissue engineering. Bone marrow mesenchymal stem cells (MSCs) are able to self-renew and capable to differentiate into multi lineage including tenocytes. Therefore, it is possible that MSCs could serve as seed cells in tendon tissue engineering. In the present invention, method and culture medium for promoting human bone marrow mesenchymal stem cells (MSCs) differentiation into tenogenic lineage is provided.

Year:  2013

Country:  WO

Doc No:  2013176538

 

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