23 Jul Temperature-sensitive polymer, synthesis method thereof and temperature-sensitive injectable hydrogel
Abstract
The invention discloses temperature-sensitive polymer, a synthesis method thereof and temperature-sensitive injectable hydrogel. A temperature-sensitive polymer is obtained by synthesizing GelMA and UPyMA, dispersing UPyMA, GelMA and MEOnMA monomers in an alkaline water solution of 8-11 in pH, removing oxygen, adding an oxidative reduction initiator or a water soluble initiator at room temperaturefor polymerization reaction until reaction is sufficient, purifying a product, and removing a solvent to obtain the temperature-sensitive polymer. The temperature-sensitive polymer can be prepared into injectable aqueous-phase temperature-sensitive polymer sol when being not higher than corresponding low critical phase transition temperature and not lower than water freezing point in a normal-pressure environment, and the sol can immediately form gel when being higher than the corresponding low critical phase transition temperature. The temperature-sensitive injectable hydrogel has dynamic mechanical performance and high biocompatibility and can be applied in the field of biomedicine like tissue engineering, drug controlled release and cell three-dimensional culture.
Year: 2019
Country: CN
Doc No: 109734851