23 Jul Synthesis and coating method of double bionic dopamine and phosphorylcholine substance
Abstract
The invention discloses a synthesis and coating method of a double bionic dopamine and phosphorylcholine substance. The synthesis and coating method comprises the following steps of enabling a vinyl monomer containing a phosphorylcholine group and dopamine hydrochloride to generate Michael addition reaction in a polarity solvent at certain temperature, so as to obtain the double bionic dopamine and phosphorylcholine substance; thinning a reaction solution, coating the surface of the to-be-modified material, airing, heating at high temperature, treating by a Tris-HCl solution, adhering to the surface of a substrate, and building a bionic cell outer membrane structure. A preparation method of a coating with the bionic cell outer membrane structure has the advantages that the preparation method is simple, and the conditions are mild; a novel path is provided for obtaining a stable phosphorylcholine bionic coating, and the important academic meaning is realized for modifying the biological compatibility of the biological material. A modifying material with the bionic cell outer membrane structure has broad application prospect in the fields of in-vivo implant materials, tissue engineering, medicine slow release, biological sensors and the like.
Year: 2017
Country: CN
Doc No: 106832382