23 Jul Surface-modified acellular matrix and modifying method thereof
Abstract
The invention belongs to the field of tissue engineering, and particularly relates to a surface modifying method of an acellular matrix. The method includes the following steps of firstly, conductingcarboxyl activating on the acellular matrix; secondly, conducting carboxyl protecting on phenylalanine or phenylalanine derivatives, and conducting grafting modifying on the carboxyl-protecting phenylalanine or phenylalanine derivatives through amino of the phenylalanine or phenylalanine derivatives and carboxyl of the acellular matrix; thirdly, conducting postprocessing on the grafting-modified acellular matrix to obtain the surface-modified acellular matrix. The improved acellular matrix has functions of resisting tumor cell and inflammatory cell infiltration, resisting infection, resistingmatrix metal protease and lactic acid degradation and improving the inflammation environment and can be used for postoperative tissue repairing of tumor treatment.
Year: 2018
Country: CN
Doc No: 107998453