23 Jul Supermolecular hydrogel containing chitosan and gelatin as well as preparation method and application of supermolecular hydrogel
Abstract
The invention provides supermolecular hydrogel containing chitosan and gelatin as well as a preparation method and an application of the supermolecular hydrogel and belongs to the field of biomaterials. The supermolecular hydrogel contains a part formed by combining chitosan modified with a beta-cyclodextrin carboxylated derivative and gelatin under the host-guest interaction; chitosan is graftedwith the beta-cyclodextrin carboxylated derivative through an amide group. The preparation method comprises the steps as follows: the chitosan is grafted with the activated beta-cyclodextrin carboxylated derivative through the amide group, then, the gelatin is added, so that the grafted beta-cyclodextrin carboxylated derivative and an aromatic group of the gelatin are in host-guest interaction, and the supermolecular hydrogel containing the chitosan and the gelatin is obtained. The supermolecular hydrogel containing the chitosan and the gelatin has shear thinning and self-healing characteristics and can be used as an injectable cell or drug carrier. The beta-cyclodextrin group in hydrogel and the aromatic group in the gelatin can be used in cell carriers and tissue engineering materials through the host-guest interaction.
Year: 2018
Country: CN
Doc No: 108467498