23 Jul Strontium-doped hydroxyapatite surface-grafted poly(Epsilon-caprolactone) composite and preparation method thereof
Abstract
The invention relates to a strontium-doped hydroxyapatite surface-grafted poly(Epsilon-caprolactone) composite and a preparation method thereof. The method comprises: preparing strontium-doped hydroxyapatite nanoparticles by means of an acid-alkali method, activating the nanoparticles at high temperature, using the nanoparticles as an initiator to initiate ring opening polymerization of Epsilon-caprolactone under catalysis of stannous octoate so as to prepare an organic/inorganic hybrid composite. The strontium-doped hydroxyapatite nanoparticles having good osteogenic induction activity and high mechanical strength and poly(Epsilon-caprolactone) having good softness, processibility, biocompatibility and drug permeability are effectively fused together; the defects that an inorganic material is highly crispy and poor in dispersity and purely poly(Epsilon-caprolactone) material has poor bioactivity are overcome; the composite has a promising development prospect in the field of bone tissue engineering repairing.
Year: 2016
Country: CN
Doc No: 105669960