23 Jul Stress active tissue engineering scaffold material and preparation method thereof
Abstract
The invention relates to a stress active tissue engineering scaffold material prepared from polyvinylidene fluoride nanofiber, silk fibroin, polyvinyl alcohol, and a preparation method thereof, and belongs to the field of a biomedical material. In the stress active tissue engineering scaffold material, the mass ratio of the silk fibroin to the polyvinyl alcohol is 1/9 to 1/1; the mass ratio of the polyvinylidene fluoride nanofiber to the polyvinyl alcohol is 1/99 to 5/95. The preparation method is characterized in that polyvinylidene fluoride nanofiber suspension, silk fibroin solution or silk fibroin powder dispersion liquid and polyvinyl alcohol solution are mixed to obtain uniform and stable mixed suspension; casting mold forming, cryocoagulation, demoulding and freeze drying are performed to obtain cavernous bodies; then, gaseous esterification treatment is performed to prepare the stress active tissue engineering scaffold material. The stress active tissue engineering scaffold material has uniform and stable micro-structures and good biocompatibility; the substrate conditions of the biological tissue growth are provided; the piezoelectric stress response characteristics of the material suffering from external force are realized.
Year: 2017
Country: CN
Doc No: 106390197