23 Jul SPONGE-LIKE POROUS APATITE-COLLAGEN COMPOSITE, SPONGE-LIKE SUPERPOROUS APATITE-COLLAGEN COMPOSITE AND PROCESS FOR PRODUCING THE SAME
Abstract
In the field of regeneration therapy engineering, there have been vigorously made research and development of apatite-collagen composites. However, existing composites cannot always satisfy various requirements such as holding a physiologically active substance or stem cells such as osteoblasts for a definite period of time, accelerating the infiltration of cells, and being replaced by a new tissue through spontaneous metabolism. Under these circumstances, it is intended to provide composites fulfilling these requirements. Namely, composites of apatite carbonate, which is highly close to bone in chemical composition and crystalline structure, and collagen having an excellent compatibility with biological tissues are formed. These composites have a porous or superporous sponge-like structure, which makes it possible to surely hold a physiologically active substance or stem cells for a definite period of time. Thus, a composite having excellent cell infiltration properties and metabolic properties can be obtained.In the field of regeneration therapy engineering, there have been vigorously made research and development of apatite−collagen composites. However, existing composites cannot always satisfy various requirements such as holding a physiologically active substance or stem cells such as osteoblasts for a definite period of time, accelerating the infiltration of cells, and being replaced by a new tissue through spontaneous metabolism. Under these circumstances, it is intended to provide composites fulfilling these requirements. Namely, composites of apatite carbonate, which is highly close to bone in chemical composition and crystalline structure, and collagen having an excellent compatibility with biological tissues are formed. These composites have a porous or superporous sponge−like structure, which makes it possible to surely hold a physiologically active substance or stem cells for a definite period of time. Thus, a composite having excellent cell infiltration properties and metabolic properties can be obtained.
Year: 2003
Country: WO
Doc No: 3047645