23 Jul Sodium alginate-modified gelatin-modified dopamine composite scaffold and preparation method thereof
Abstract
The invention discloses a sodium alginate-modified gelatin-modified dopamine composite scaffold and a preparation method thereof. The preparation method comprises the following steps: double-bond modification of gelatin and dopamine; preparation of three-dimensional printing slurry; and three-dimensional printing and molding of the scaffold for tissue engineering. According to the invention, a small amount of calcium ions are used for pre-crosslinking so as to obtain the slurry beneficial for printing and molding and similar to high-solid-content inorganic powder; the prepared scaffold can maintain its three-dimensional porous structure; preparation of the printing slurry is optimized; printing is carried out without too many supplementary conditions; and materials are greatly saved. The preparation method for the composite scaffold prepared in the invention has the advantages of mild conditions, simple process and easy realization. The prepared composite scaffold can be used in the fields of skin repair, drug sustained-release, tissue engineering, etc.
Year: 2017
Country: CN
Doc No: 107308505