23 Jul Sodium alginate and chitosan skin tissue engineering scaffold material and preparation method thereof
Abstract
The invention relates to a sodium alginate and chitosan skin tissue engineering scaffold material and a preparation method thereof. According to the scaffold material, sodium alginate and chitosan take CaCl2 as a crosslinking agent to form a scaffold base, and the mass ratio of the sodium alginate to the chitosan is 5:3-3:5; and a grid structure formed by the sodium alginate is crosslinked by the CaCl2 and put on a sodium alginate and chitosan scaffold base in an interlayer mode, the grid size of the sodium alginate is (1-2)*(1-2)mm<2>, and the height is 0.2 to 0.5mm. By the scaffold material, the sodium alginate and the chitosan base which can be completely degraded are taken as base materials; by combining an interlayer manufactured by a rapid prototyping (RP) technology, the mechanical strength of the sodium alginate and chitosan scaffold material can be improved; and the pore diameter of a scaffold is 100 to 150mu m, the porosity is more than 90 percent, and the tensile strength reaches 1 to 8 MPa. The scaffold material has high biocompatibility and is suitable for growth and proliferation of cells.
Year: 2013
Country: CN
Doc No: 102886070