23 Jul SILK FIBROIN SYSTEMS FOR ANTIBIOTIC DELIVERY
Abstract
The present invention provides for silk fibroin-based compositions comprising one or more antibiotic agents for prevention or treatment of microbial contamination, methods of making antibiotic-containing silk scaffold, methods of stabilizing antibiotics in silk scaffolds, and methods for preventing or treating microbial contamination using the antibiotic-containing compositions. Various methods may be used to embed the antibiotic(s) into the silk fibroin-based compositions. The antibiotic-containing compositions of the invention are particular useful for stabilizing antibiotics, preventing bacterial infections, and for medical implants, tissue engineering, drug delivery systems, or other pharmaceutical or medical applications. WO 2010/141133 PCT/US2010/026190 / 4-Y — —– 0. G — S- M icrospheres in Scaffold – Layered on Scaffold -v Emrbedded in Scaffold — Layered on Siik M1Iat CO 20 40 60 so 100 120 14 0 16O0 18 Time (Hours) Figure 1 0 AS – ;C .4- -7-k 4y — Microspheres n Scaffold — ‘- Layered on Scaffold -v- Layered on Sik Mat – 7- Eimbedded in Scaffold 0 20 40 60 80 10C 120 140 160 180 Time (Hours) Figure 2
Year: 2018
Country: AU
Doc No: 2018267539