23 Jul Self-assembly collagen template tissue engineering material as well as preparation method and application thereof
Abstract
The invention discloses a self-assembly collagen template tissue engineering material as well as a preparation method and application thereof, and belongs to the field of biomedical materials. The self-assembly collagen template tissue engineering material is prepared from collagen and polyhydroxy alcohol by cross-linking and solidification through glutamine transaminase. The preparation method is simple, and is convenient to operate, controllable in process parameter and low in cost. The cross-linking by adopting a microbial enzyme is superior to that by adopting other cross-linking agents; the toxic and side effects of, for example, methacrylic anhydride (MA), a photoinitiator and the like to a cell are avoided; the obtained material has better biological activity, biocompatibility and mechanical properties, can be used for constructing a better three-dimensional scaffold system for the growth of the cell, and can be also used for loading a medicine. The material can be used for the generation of new tissue and the repair of injured tissue, and is clinically used for the fields of tissue engineering of cartilage, bones, skin, blood vessels and the like.
Year: 2016
Country: CN
Doc No: 105802251