23 Jul SELF-ASSEMBLING MULTICELLULAR BODIES AND METHODS FOR PREPARING THREE-DIMENSIONAL BIOLOGICAL STRUCTURES USING THE SAME
Abstract
PROBLEM TO BE SOLVED: To provide means enabling construction of three dimensional vascularized organs.SOLUTION: Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an artificial tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and ingrowth of cells from the multicellular bodies and also resists adherence of cells to it. Three-dimensional constructs can be assembled by printing or otherwise stacking the multicellular bodies and filler bodies such that there is direct contact between adjoining multicellular bodies, suitably along a contact area of a substantial length. The direct contact between the multicellular bodies promotes efficient and reliable fusion. The increased contact area between adjoining multicellular bodies also promotes efficient and reliable fusion.
Year: 2015
Country: JP
Doc No: 2015023867