23 Jul SELF-ASSEMBLED THIN FILM COATING TO ENHANCE THE BIOCOMPATIBILITY OF MATERIALS
Abstract
We make a subtrate biocompatible by contacting it with a starting material a nd initiating alternating charge layer electrostatic self-assembly to form a th in film. Starting materials may be poly(vinylpyrrolidone), poly{bis- (carboxylatophenoxy)phosphazene}, poly(methacrylic acid), poly(l)-lysine, poly(ethylene glycol), poly(D-glucosamine), poly(l-glutamic acid), poly(diallyldimethylamine), poly(ethylenimine), hydroxy fullerene, long- sidechain fullerene, or other polymers that participate in electrostatic sel f- assembly. The thin film fabrication advantageously may be at room temperatur e. A biocompatible thin film that is uniform and homogeneous can be provided. Optionally, ZrO2, Al2O3 or TiO2 nanoclusters also may be used in the film assembly. The film may be used in a drug delivery device or a medical device . The film may be used for tissue engineering. We also provide a biocompatible composition in which are present a plurality of layers electrostatically sel f- assembled from at least a polymer or fullerene asmentioned. The substrate is not particulary limited, and may be quartz, glass, plastic, metal or ceramic , a material for a bone implant, bioactive glass, polyester or other polymers, plastic or rubber tubing, bandaging material, composite material, insulator material, semi-conductor material, an artificial hip, a pacemaker, a cathete r, a stent or other substrates.
Year: 2001
Country: CA
Doc No: 2405242