23 Jul Ring aliphatic carbonate monomer, polymer and preparation method thereof
Abstract
The invention provides a cyclic aliphatic carbonate monomer including 2′-benzyloxygenamide trimethylene carbonate and 2-methyl-2-benzyloxygenamide trimethylene carbonate and the polymer and the preparation method thereof. The raw material for the preparation of the two monomers is 2-amino-1,3-propanediol and 2-methyl-2-amino-1,3-propanediol, the amino group is protected, and the hydroxyl group at two ends and ethyl cacodylic acid chloroformate react to produce the monomer. The polymer with the amino at the protective side is obtained by the homopolymerization of the monomer or the copolymerization of the monomer and the aliphatic cyclic ester, and then the polymer with the side amino is obtained after escaping the protection of the polymer. The functional side amino of the polymer can be loaded with the drug molecules and the bioactive peptide by the covalent bond and the ionic bond. Thereby the invention can be applied in the fields of the drug controlled release, the gene therapy and the tissue engineering.
Year: 2008
Country: CN
Doc No: 101200462