23 Jul Reductively biodegradable type honeycomb polyurethane support, and preparation method and application thereof
Abstract
The invention discloses a reductively biodegradable type honeycomb polyurethane support, and a preparation method and application thereof. The preparation method comprises: taking 2,2′-dithiodiethanol as an initiator, employing a ring-opening polymerization method to synthesize double-hydroxy-terminated polycaprolactone containing disulfide bonds; reacting with diisocyanate containing a disulfide bond to form polyester type polyurethane containing disulfide bonds; then dipping a biological template wisteria sinensis with a sodium chloride solution and calcining to obtain a negative template porous sodium chloride of wisteria sinensis; and finally immersing the negative template porous sodium chloride of wisteria sinensis with a waterless organic solution of the polyester type polyurethane containing disulfide bonds, drying and removing the negative template to obtain the honeycomb polyurethane support, wherein the molecular structural formula of the polyurethane is shown in the description. The reductively biodegradable type honeycomb polyurethane support has the advantages of simple technology, easy batch preparation, and strong biodegradation controllability; and the honeycomb structure is beneficial to transportation of substances inside or outside the support, the support can be used as a porous support for tissue regeneration repair, and belongs to a tissue engineering support material with excellent comprehensive performances.
Year: 2014
Country: CN
Doc No: 103495203