23 Jul Quaternised chitosan-polycaprolactone grafting copolymer, preparation, reticulate membrann prepared by the copolymer and method for preparing the copolymer
Abstract
The invention discloses a quaternary ammonium chitosan-polycaprolactone grafted copolymer and a preparation method thereof as well as a reticular membrane prepared by the copolymer and a method thereof, wherein, the polycaprolactone branched chain of the uaternary ammonium chitosan-polycaprolactone grafted copolymer is grafted on the chitosan C-6 position, the 2-hydroxy-3-methyl amine propyl chloride side chain is connected to the chitosan C-2-position, and the obtained grafted copolymer material is loaded with selected drugs by a method of solution mixing and assembled into a gradient-structured reticular membrane by using the electro-wet spinning technology. The membrane has the advantages of good mechanical properties, adjustable pore structure, bio-degradability, moisture retention and air permeability, anti-bacterial and bactericidal capacity and drug controlled release capacity. The process of material synthesizing and processing and preparation for the membrane is simple, the grafted copolymer material structure and the membrane structure are adjustable, the drug release rate is controllable, and the adopted raw materials are mainly natural biological material and have rich sources. The membrane can be used in the treatment of different degrees of skin injury and in the tissue engineering scaffolds for follow-up skin tissue repair.
Year: 2009
Country: CN
Doc No: 101486774