23 Jul Prussian blue microneedle electrode for blood glucose monitoring, preparation method thereof, blood glucose monitoring patch and preparation method thereof
Abstract
The invention belongs to the field of biomedical engineering, and particularly relates to a prussian blue microneedle electrode for blood glucose monitoring, a preparation method thereof, a blood glucose monitoring patch and a preparation method thereof. The prussian blue microneedle electrode provided by the invention comprises a gold microneedle electrode, wherein the gold microneedle electrodecomprises a gold microneedle electrode substrate and a plurality of gold microneedles, wherein the bottoms of the gold microneedles are fixed on the gold microneedle electrode substrate; a prussian blue layer compounded on the surface of the gold microneedle; and a chitosan immobilized glucose oxidase layer compounded on the surface of the prussian blue layer. According to the invention, the problem of tedious work caused by blood drawing test required for diabetes blood glucose monitoring at present is solved; the glucose concentration in the tissue fluid can be rapidly and accurately testedfor a long time only by penetrating the microneedle electrode provided by the invention through the cuticle of the skin, and the microneedle electrode is small in size and convenient to carry, and hasthe potential of serving as a good safe, portable and painless blood glucose electrochemical sensor.
Year: 2019
Country: CN
Doc No: 110558993