23 Jul PROCESS OF DECELLULARIZING BIOLOGICAL MATRICES AND ACELLULAR BIOLOGICAL MATRICES USEFUL IN TISSUE ENGINEERING
Abstract
A method of decellularizing a biological matrix so as to obtain an acellular biological matrix, as well as clinical uses of the acellular biological matrix are disclosed. The method is effected by (a) obtaining a tissue of interest; (b) treating the tissue of interest with a decellularization solution containing a cell lysis reagent, preferably a combination of a non-ionic detergent with a mild base; (c) removing cell remnants, thereby obtaining the acellular biological matrix; and optionally (d) dehydrating the acellular biological matrix.
Year: 2002
Country: WO
Doc No: 240630