23 Jul Process method for synthesizing lactic acid-lysine copolymer by catalytically opening loop and copolymerizing with acetic bicyclo-guanidine
Abstract
The invention discloses a process method for synthesizing a lactic acid-lysine copolymer by catalytically opening a loop and copolymerizing with acetic bicyclo-guanidine (the molar content of diaminocaproic acid is 1-5 percent). The lactic acid-lysine copolymer is synthesized by taking acetic bicyclo-guanidine as a catalyst, taking lactide and lysine morpholine diketone as monomers, performing body loop opening copolymerization and undergoing a phenmethyl carboxide removing action. The process method has characteristics that: the acetic bicyclo-guanidine serving as a catalyst is bionic organic guanidinium which is effective, nontoxic and free from metals; the monomer transformation ratio is high (more than or equal to 95 percent); the yield is over 93 percent; a product does not contain any metal or other toxic residue, and has high biological safety; the number average molecular weight is adjustable in the range of 1.5-2.8*10<4>, and the molecular weight distribution is narrow (PDI (Protein Disulfide Isomerase) is less than or equal to 1.30); the molar content of lysine in the copolymer is adjustable in the range of 1-5 percent; and the synthesized lactic acid-lysine copolymer isan amphiphilic functional group biodegradable polymer, is suitable for serving as targeted and controlled release medicament carriers, and can be applied on other aspects in the field of biological medical tissue engineering.
Year: 2012
Country: CN
Doc No: 102504227