23 Jul PROCESS FOR THE DEPOSITION OF BIOMATERIALS ON WATER REPELLENT SUBSTRATES AND RESULTING BIOMATERIALS
Abstract
The present invention relates to a process for the deposition of biomaterials on surfaces involving the patterning of areas with different surface tensions at the surface of the substrates with high repellence to water, through a treatment that increases wettability, such as a treatment with ultraviolet radiation and ozone or plasma. Another aspect of the present invention relates to the substrates comprising areas with differences of surface tension, which present specific and controllable wettability properties, which are useful for the controlled deposition of solutions of biomaterials confined to the wettable regions, allowing for their individual manipulation and analysis. A third aspect of the present invention relates to the products or devices comprising biomaterials deposited on the substrates. The present process presents as an advantage the possibility of depositing independent combinations of biomaterials, such as proteins, genes, cells and culture media in independent regions of the same treated substrate, being consequently useful for the analysis of the performance of the biomaterials in various biological environments, and an added-value in the production of biomaterials in the fields of tissue engineering, regenerative medicine, cell biology, development of pharmaceutical drugs, and the monitoring of the administration of drugs and diagnosis.
Year: 2012
Country: WO
Doc No: 2012078066