23 Jul Preparation technology of porous extracellular matrix bracket
Abstract
The invention discloses a preparation technology of a porous extracellular matrix bracket, aiming at solving the problems of an extracellular matrix bracket material that the pore diameter is small and cellularization is poor. Specifically, after a degradable polymer micro-sphere aggregate is planted into a subcutaneous tissue, muscle or an abdominal cavity of a host, a host cell is transferred into a micro-sphere aggregate pore to realize cellularization; after a cellularized micro-sphere aggregate bracket material is subjected to polymer elution and decellularization treatment in sequence, the extracellular matrix bracket can be obtained. The process can be used for controlling the size of the pore diameter of the bracket through controlling the size of the polymer micro-sphere; meanwhile, the connectivity of the bracket is controlled through controlling the splicing degree of the polymer micro-sphere. The porous extracellular matrix bracket prepared by the invention has a good application prospect in the fields of tissue engineering including stem cell transplantation, cartilage repairing, skin repairing and the like.
Year: 2016
Country: CN
Doc No: 105999423