23 Jul Preparation, raw material, product and application of photo-coupling co-crosslinking hydrogel material
Abstract
The invention provides a preparation method, a raw material, a product and an application of a photo-coupling co-crosslinking hydrogel material. The preparation method comprises the steps of dissolving a component A, namely an o-nitrobenzyl photo-trigger modified high polymer derivative in a biocompatible medium to obtain a solution A, dissolving a component B, namely an amidogen-containing high polymer derivative or a double bond containing high polymer derivative or a sulfydryl containing high polymer derivative in the biocompatible medium to obtain a solution B, uniformly mixing the solution A (or adding the solution B) to obtain a hydrogel precursor solution, illuminating the hydrogel precursor solution under a light source, and allowing o-nitrobenzyl groups in the component A to generate aldehyde groups/ketonic groups or nitroso-groups by optical excitation for double crosslinking to exert a co-crosslinking effect. The invention further provides a reagent kit for preparing hydrogel, and the application of the hydrogel material in tissue engineering, regeneration medicine and 3D (three dimensional) printing and as a cell, protein or drug carrier.
Year: 2019
Country: CN
Doc No: 109776450