23 Jul Preparation of self-healing and template-free porous scaffold
Abstract
The invention provides a self-healing porous scaffold material and a preparing method thereof. The method specifically comprises the following steps: performing aldehyde modification on sodium alginate to obtain oxidized sodium alginate (OSA), dissolving OSA and gelatin respectively in a PBS (poly butylenes succinate) solution, taking a certain amount of the two sets of solutions for mixture, adding a certain amount of PBS solution containing adopyl diacidhydrazine, performing high-speed shearing and mixing for 10 s to 3 min, and crosslinking at 37 to 60 DEG C for 30 s to 3 min, to obtain the sodium alginate-gelatin porous scaffold material. The method has simple preparing processes, controllable conditions without a porous template; the porous scaffold biological material obtained through preparation has a self-healing performance and characteristics such as good biocompatibility, mechanical property, and macropore performances at the same time. the scaffold material can be widely applied to biomedical fields such as biological scaffolds, cell culturing, drug control, and tissue engineering.
Year: 2017
Country: CN
Doc No: 106693067