23 Jul Preparation of amorphous calcium phosphate/polylactic acid electrostatic spinning bracket
Abstract
The invention provides a preparation method of a composite nano-fiber material and belongs to the field of biomedical materials. Amorphous calcium phosphate ceramic is added into polylactic acid nano-fibers through an electrostatic spinning method so that the bioactivity of the material is improved; the composite nano-fiber material provides Ca<2+> and PO4<3->, which are used for promoting bone cell proliferation and differentiation, for bone tissue repairing; the polylactic acid can be used as a scaffold material for bone defects; amorphous calcium phosphate is precipitated again and converted into a basic component hydroxyapatite of bone tissues along the formation of new bones; the polylactic acid is degraded in bodies to form CO2 and H2O and then is circularly discharged out of the bodies; the amorphous calcium phosphate is added and inflammatory response caused by acid generated by degradation of the polylactic acid is alleviated. The invention provides a new concept for further development of bone tissue engineering and the preparation method has important theoretical and practical significance.
Year: 2017
Country: CN
Doc No: 107126582