23 Jul Preparation method of thermosensitive hydrogel with adhesiveness and antibacterial activity
Abstract
The invention discloses a preparation method of thermosensitive hydrogel with adhesiveness and antibacterial activity. Firstly, natural chitosan is subjected to hydroxybutylation modification to havethermosensitivity (patent number: 201110214776.X); secondly, HBC (hydroxybutyl chitosan) is grafted with L-DOPA (levodopa) with the chemical name of 3-hydroxy-L-tyrosine, and L-DOPA contains catechingroups, so that the hydrogel has good adhesiveness; then, HBC is grafted with EPL (epsilon-poly-L-lysine), EPL is a polypeptide and has the antibacterial efficacy by use of protonated amino groups. The composite gel material has adhesiveness and antibacterial activity and possibly has wide application prospects in the aspects of tissue engineering and skin repairing.
Year: 2018
Country: CN
Doc No: 108096631