23 Jul Preparation method of spider silk protein-collagen composite hydrogel with high mechanical strength
Abstract
The invention discloses a preparation method of a spider silk protein-collagen composite hydrogel with high mechanical strength, and belongs to the technical field of hydrogels. The method comprises the steps that spider silk proteins are dissolved in formic acid and collagen is dissolved in an acid solution to obtain a spider silk protein formic acid solution and a collagen acid solution, the spider silk protein formic acid solution is added dropwise to the collagen acid solution, the mixed solution is neutralized by an alkaline solution to enable the pH to be neutral and subjected to standing at a room temperature, and the spider silk protein-collagen composite hydrogel is formed. The composite hydrogel prepared by the preparation method has biodegradability, biocompatibility and cell adhesion. The spider silk proteins are added to significantly improve the mechanical properties of the composite hydrogel. The preparation technology is simple and easy to operate. The preparation process does not involve toxic and side effect reagents, the composite hydrogel is environmentally friendly, is low in cost, and has broad application prospects in tissue engineering, medicine and other fields.
Year: 2020
Country: CN
Doc No: 110684208