23 Jul Preparation method of silk fibroin/metal nanoparticle composite system
Abstract
The invention provides a preparation method of a silk fibroin/metal nanoparticle composite system, belonging to the technical field of nanocomposite materials and preparation methods thereof. The preparation method comprises the steps of fully mixing metal nanoparticles with silk fibroin in a weight ratio of (1:9)-(9:1) so that silk fibroin is non-covalently adsorbed on the surfaces of the metal nanoparticles, thus obtaining the silk fibroin/metal nanoparticle composite system. The metal nanoparticles in the composite system prepared by the preparation method can not aggregate under the conditions that the pH value is 2-11 and the salinity is 0-1000mM, thus improving the stability and biocompatibility of the metal nanoparticles in the physiological environment. The silk fibroin/metal nanoparticle composite system provided by the invention is simple to prepare, is low in cost, has good stability and biocompatibility and has wide application prospects in the biomedical fields of drug sustained release, gene transmission, tissue engineering and the like.
Year: 2013
Country: CN
Doc No: 103468002