23 Jul Preparation method of POSS (Polyhedral Oligomeric Silsesquioxane) hybrid hydrogel capable of being degraded in acid and responding to temperature
Abstract
The invention relates to a preparation method of a hydrogel capable of rapidly responding to temperature change and being slowly degraded in an acid environment. The hydrogel is obtained through free radical solution polymerization at 60 DEG C under the protection of nitrogen gas by taking N-isopropylacrylamide and vinyl pyrrolidone as comonomers and octa(vinyl) polyhedral oligomeric silsesquioxane and 3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5]undecane as co-crosslinking agents. The hydrogel is stable in a non-acid environment and has remarkable thermosensitivity, and the LCST (Lower Critical Solution Temperature) of the hydrogel is close to the temperature of a human body. When the hydrogel is in the acid environment, parts of crosslinking bonds in the hydrogel rupture so that the hydrogel is slowly degraded. Meanwhile, the hydrogel is better in pressure resistance and high in responsive swelling and deswelling velocity so as to be potentially applied to the fields of oriented drug sustained release and biological tissue engineering.
Year: 2013
Country: CN
Doc No: 103145916