23 Jul Preparation method of polycaprolactone tissue engineering scaffold
Abstract
The invention relates to a preparation method of a polycaprolactone tissue engineering scaffold. The method includes preparing 25-40% of polycaprolactone, 30-45% of polyoxyethylene and 25-40% of sodium bicarbonate into mixed solution, performing spinning to obtain polycaprolactone nanofibers, treating the nanofibers in supercritical CO2 to obtain an intermediate product by means of controlling treatment pressure and treatment temperature, and subjecting the obtained intermediate product to percolation in circulating water bath prior to vacuum drying to obtain the tissue engineering scaffold made of a porous material with the porosity reaching 68-74.0%, the cell size being 20-200 microns and the size of internally mutually communicated channels being about 20-200 microns. The preparation method can finish inter-fiber crosslinking and fusion at low temperature without solvent, cross-linking agent and the like, and cytotoxicity is avoided.
Year: 2017
Country: CN
Doc No: 106492289