23 Jul Preparation method of poly hydroxybutyrate caproic-acid copolyester tissue engineering scaffold
Abstract
The invention relates to a preparation method of a poly hydroxybutyrate caproic-acid copolyester tissue engineering scaffold. The preparation method comprises the steps that after 25-40% of poly hydroxybutyrate caproic-acid copolyester, 30-45% of polyoxyethylene and 25-40% of sodium bicarbonate are prepared into a mixed solution, spinning is performed to obtain poly hydroxybutyrate caproic-acid copolyester nanofiber, the nanofiber is processed in supercritical CO2, an intermediate product is prepared by controlling the processing pressure and processing temperature, the obtained intermediate product is drained and filtered in a circulating water bath and then is subjected to vacuum drying, and the tissue engineering scaffold with the porosity up to 68-74.0%, the bubble hole size of 20-200 microns and the internal intercommunication channel size of about 20-200 microns and made from a porous material can be obtained. The preparation method can complete fiber crosslinking and fusion between in a low temperature state without solvents, crosslinking agents and the like, and cytotoxicity is not produced.
Year: 2017
Country: CN
Doc No: 106620881