23 Jul Preparation method of nano hydroxyapatite grafted polyhydroxybutyrate-hydroxyvalerate (PHBV)
Abstract
The invention discloses a preparation method of nano hydroxyapatite grafted polyhydroxybutyrate-hydroxyvalerate (PHBV), which mainly comprises the following steps: (1) introducing amino groups on PHBV molecules by utilizing an ammonia plasma processing method; (2) processing PHBV after amination by utilizing glutaraldehyde so as to carry out hydroformylation on PHBV; (3) processing nano hydroxyapatite by utilizing a silane coupling agent so as to carry out amination on nano hydroxyapatite; and (4) reacting PHBV after hydroformylation and nano hydroxyapatite after amination to obtain PHBV grafted nano hydroxyapatite. The method disclosed by the invention effectively solves the problem that nano hydroxyapatite is easy to agglomerate in a PHBV substrate; meanwhile, the method is basically carried out at normal temperature and is mild in reaction condition, simple in preparation process, relatively high in preparation efficiency and wide in application prospect; Nano hydroxyapatite grafted PHBV prepared by the method disclosed by the invention has potential application in tissue engineering and bone defect repair.
Year: 2016
Country: CN
Doc No: 105582577